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comfrey	ACETAMINOPHEN	Comfrey is an herb considered to have a potential to stress the liver and cause damage (hepatotoxic). On it's own, this would more than likely be rare unless severe liver inflammation and/or damage already existed. Acetaminophen has a hepatotoxic potential, particularly in patients with active hepatitis. Avoid the combination of these two substances.
comfrey	ALCOHOL	Alcohol is an herb considered to have a potential to stress the liver and cause damage (hepatotoxic). On it's own, this would more than likely be rare unless severe liver inflammation and/or damage already existed. Alcohol is hepatotoxic and should be avoided if taking borage.
comfrey	CLARITHROMYCIN	Colt's foot is an herb considered to have a potential to stress the liver and cause damage (hepatotoxic). On it's own, this would more than likely be rare unless severe liver inflammation and/or damage already existed in combination with other hepatotoxic substances can cause liver inflammation. Clarithromycin, in combination with other hepatotoxic substances, can cause liver inflammation.
comfrey	ERYTHROMYCIN	Comfrey is an herb considered to have a potential to stress the liver and cause damage (hepatotoxic). On it's own, this would more than likely be rare unless severe liver inflammation and/or damage already existed. Erythromycin, in combination with other hepatotoxic substances, can cause liver inflammation.
comfrey	ISONIAZID	Comfrey is an herb considered to have a potential to stress the liver and cause damage (hepatotoxic). On it's own, this would more than likely be rare unless severe liver inflammation and/or damage already existed. Isoniazide, a drug used to treat tuberculosis, is considered to have a hepatotoxic potential. Avoid the combination of these two substances.
comfrey	METHOTREXATE SODIUM	Comfrey is an herb considered to have a potential to stress the liver and cause damage (hepatotoxic). On it's own, this would more than likely be rare unless severe liver inflammation and/or damage already existed. Methotrexate is a cancer chemotherapeutic agent that has other uses such as in rheumatoid arthritis or severe psoriasis. It is a drug that has a high hepatotoxic potential particularly if used for a long duration of time. Avoid this combination of substances.
comfrey	METHYLDOPA	Comfrey is an herb considered to have a potential to stress the liver and cause damage (hepatotoxic). On it's own, this would more than likely be rare unless severe liver inflammation and/or damage already existed. Methyldopa is and older antihypertensive that can be hepatotoxic, particularly in women. Avoid this combination.
comfrey	NIACIN	Comfrey is an herb considered to have a potential to stress the liver and cause damage (hepatotoxic). On it's own, this would more than likely be rare unless severe liver inflammation and/or damage already existed. High dose niacin used to treat dyslipidemia and it's resultant high triglycerides and LDL cholesterol, can be hepatotoxic. The combination of high dose niacin and borage could cause stress to the liver.
comfrey	PHENYTOIN	Colt's foot is an herb considered to have a potential to stress the liver and cause damage (hepatotoxic). On it's own, this would more than likely be rare unless severe liver inflammation and/or damage already existed. The anticonvulsant phenytoin also known as Dilantin@, is hepatotoxic in certain people with a genetic predisposition to slow break down of certain drugs in the liver. Use caution with the combination of these two substances.
comfrey	STATIN DRUGS	Comfrey is an herb considered to have a potential to stress the liver and cause damage (hepatotoxic). On it's own, this would more than likely be rare unless severe liver inflammation and/or damage already existed. The statin drugs, used to lower cholesterol, have a high hepatotoxic potential. This class of drugs includes atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, and simvastatin.
corn silk	AMIODARONE HYDROCHLORIDE	Corn silk is an herb with a diuretic action. This action can lead to depletion of potassium. Low potassium levels can increase the occurrence of cardiac arrhythmias (irregular, often rapid heart beat). This herb should be taken cautiously if you are taking medication, like amiodarone, to correct or control an underlying cardiac arrhythmia.
corn silk	CORTICOSTEROIDS	Corn silk may cause increased side effects of depletion of potassium and possible fluid imbalances if taken with the oral corticosteroids. Oral corticosteroids includes betamethasone, cortisone, dexamethasone, fludrocortisone, hydrocortisone, prednisolone, and prednisone.
corn silk	DIGOXIN	Corn silk is an herb with a diuretic action. This action can lead to depletion of potassium. Low potassium levels can increase the occurrence of cardiac arrhythmias (irregular, often rapid heart beat). This herb should be taken cautiously if you are taking medication, like digoxin, to correct or control an underlying cardiac arrhythmia and rapid heart beat.
corn silk	FLECAINIDE ACETATE	Corn silk is an herb with a diuretic action. This action can lead to depletion of potassium. Low potassium levels can increase the occurrence of cardiac arrhythmias (irregular, often rapid heart beat). This herb should be taken cautiously if you are taking medication, like flecainide, to correct or control an underlying cardiac arrhythmia.
corn silk	LITHIUM CARBONATE	Corn silk acts as a diuretic and can deplete sodium, which could lead to increased lithium side effects.
corn silk	QUINIDINE	Corn silk is an herb with a diuretic action. This action can lead to depletion of potassium. Low potassium levels can increase the occurrence of cardiac arrhythmias (irregular, often rapid heart beat). This herb should be taken cautiously if you are taking medication, like amiodarone, to correct or control an underlying cardiac arrhythmia.
cramp bark	BARBITURATES	Cramp bark is an herb that is rich in salicylates. Combined with anticonvulsant drugs like the barbiturates can cause an increase in therapeutic effect and erratic blood levels. This class of anticonvulsant includes mephobarbital, phenobarbital, primidone.
cramp bark	BENZODIAZEPINES	Cramp bark is an herb that is rich in salicylates. Combined with anticonvulsant drugs like the benzodiazepines can cause an increase in therapeutic effect and erratic blood levels. The one drug in this class used as an anticonvulsant is clonazepam.
cramp bark	HYDANTOINS	Cramp bark is an herb that is rich in salicylates. Combined with anticonvulsant drugs like the hydantoins can cause an increase in therapeutic effect and erratic blood levels. This class of anticonvulsant includes ethotoin and phenytoin.
cramp bark	METHOTREXATE SODIUM	Cramp bark is a calculate herb and can increase the blood levels of methotrexate. This could lead to toxicity, possibly from decreased excretion.
cramp bark	MISCELLANEOUS ANTICONVULSANTS	Cramp bark is an herb that is rich in salicylates. Combined with anticonvulsant drugs can cause an increase in therapeutic effect and erratic blood levels. This class of anticonvulsant includes carbamazepine, felbamate, gabapentin, levetiracetam, magnesium sulfate, oxcarbazepine, tiagabine hydrochloride, toprimate, valproic acid, and zonisamide.
cramp bark	OXAZOLIDINEDIONES	Cramp bark is an herb that is rich in salicylates. Combined with anticonvulsant drugs like the oxazolidinediones can cause an increase in therapeutic effect and erratic blood levels. This class of anticoagulant was once the drugs of choice for absence seizure but is rarely prescribed now.
cramp bark	SUCCINIMIDES	Cramp bark is an herb that is rich in salicylates. Combined with anticonvulsant drugs like the succinimides can cause an increase in therapeutic effect and erratic blood levels. This class of anticonvulsant includes ethosuximide and methsuximide.
current, black	BARBITURATES	The oil of black current is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the benzodiazepines, could potentially decrease the therapeutic effect. This class of anticonvulsant includes mephobarbital, phenobarbital, primidone.
current, black	BENZODIAZEPINES	The oil of black current is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the benzodiazepines, could potentially decrease the therapeutic effect. The one benzodiazepine that is used as an anticonvulsant is clonazepam.
current, black	BUPROPION HYDROCHLORIDE	Black current oil is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. There is an additive effect of this action if taken with a medication like bupropion, also known as Wellbutrin@, which can lower the seizure threshold as well. The risk of having a seizure, particularly in someone with a known seizure disorder is increased.
current, black	HYDANTOINS	The oil of black current is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the benzodiazepines, could potentially decrease the therapeutic effect. This class of anticonvulsant includes ethotoin and phenytoin.
current, black	MISCELLANEOUS ANTICONVULSANTS	The oil of black current is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the benzodiazepines, could potentially decrease the therapeutic effect. This class of anticonvulsant includes carbamazepine, felbamate, gabapentin, levetiracetam, magnesium sulfate, oxcarbazepine, tiagabine hydrochloride, toprimate, valproic acid, and zonisamide.
current, black	OXAZOLIDINEDIONES	The oil of black current is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the benzodiazepines, could potentially decrease the therapeutic effect. This class of anticoagulant was once the drugs of choice for absence seizure but is rarely prescribed now.
current, black	SUCCINIMIDES	The oil of black current is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the benzodiazepines, could potentially decrease the therapeutic effect. This class of anticonvulsant includes ethosuximide and methsuximide.
danshen	WARFARIN SODIUM	Danshan Clover is a coumarin-rich herb and has been observed to enhance the action of warfain by increasing maximum concentration and decreasing volume of distribution. This has increased bleeding.
echinacea	BECLOMETHASONE DIPROPIONATE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune suppressing drugs like beclomethasone which is an inhaled synthetic corticosteroid used to stabilize asthma.
echinacea	BETAMETHASONE DIPROPIONATE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune response suppressing drugs like betamethasone dipropionate, a synthetic glucocorticoid.
echinacea	BETAMETHASONE VALERATE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune response suppressing drugs like betamethasone dipropionate, a synthetic glucocorticoid.
echinacea	CORTICOSTEROIDS	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune suppressing drugs like the corticosteroids both the glucocorticoids and the mineralcorticoids which includes beclomethasone, betamethasone, cortisone, dexamethasone, fludrocortisone acetate, flunisolide, fluticasone propionate, hydrocortisone, methylprednisolone, prednisolone, prednisone, and triamcinolone.
echinacea	CYCLOSPORINE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune suppressing drugs like cyclosporine.
echinacea	DEXAMETHASONE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune suppressing drugs like dexamethasone, a synthetic glucocorticoid steroid.
echinacea	HYDROCORTISONE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune suppressing drugs like hydocortisone, a glucocorticoid secreted by the adrenal cortex.
echinacea	METHYLPREDNISOLONE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune suppressing drugs like methylprednisolone, a synthetic glucocorticoid steroid.
echinacea	PREDNISOLONE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune suppressing drugs like prednisolone, a synthetic glucocorticoid steroid.
echinacea	PREDNISONE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune suppressing drugs like prednisone, a synthetic glucocorticoid steroid.
echinacea	TRIAMCINOLONE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune suppressing drugs like triamcinolone which is an inhaled synthetic corticosteroid used to stabilize asthma.
echinacea	TRIAMCINOLONE	Echinacea is an herb that has an immune stimulating action. It may interfere with the effectiveness of immune suppressing drugs like triamcinolone which is an inhaled synthetic corticosteroid used to stabilize asthma.
ephedra	ALPRAZOLAM	Ephedra was banned in the U.S. in 2004 because its sympathomimetic action caused cardiovascular events that could lead to death. It can still be found on the internet. It is especially dangerous when taken with drugs designed to lower the elevations in BP with hypertension causing an opposition in therapeutic action and marked elevations in BP. The class of antihypertensive drugs called Alpa Adrenergic Blockers is among them and includes doxazosin, prazosin, and terazosin.
ephedra	BETA ADRENERGIC BLOCKING AGENTS	Ephedra was banned in the U.S. in 2004 because its sympathomimetic action caused cardiovascular events that could lead to death. It can still be found on the internet. It is especially dangerous when taken with drugs designed to lower the elevations in BP with hypertension causing an opposition in therapeutic action and marked elevations in BP. The class of antihypertensive drugs called Beta Adrenergic Blockers is among them and includes acebutolol, atenolol, betaxolol, bisoprolol, carvedilol, esmolol, labetalol, metoprolol, nadolol, pindolol, propranolol, sotalol, and timolol.
ephedra	CALCIUM-CHANNEL BLOCKING AGENTS	Ephedra was banned in the U.S. in 2004 because its sympathomimetic action caused cardiovascular events that could lead to death. It can still be found on the internet. It is especially dangerous when taken with drugs designed to lower the elevations in BP with hypertension causing an opposition in therapeutic action and marked elevations in BP. The class of antihypertensive drugs called Calcium-Channel Blockers is among them and includes amlodipine, bepridil, diltiazem, felodipine, isradipine, nicardipine, nifedipine, nisoldipine, and verapamil.
ephedra	RENIN-ANGIOTENSIN SYSTEM INHIBITORS	Ephedra was banned in the U.S. in 2004 because its sympathomimetic action caused cardiovascular events that could lead to death. It can still be found on the internet. It is especially dangerous when taken with drugs designed to lower the elevations in BP with hypertension causing an opposition in therapeutic action and marked elevations in BP. The class of antihypertensive drugs called Renin-Angiotensin System Inhibitors of which there are two kinds. The older of these is the Angiotensin-Converting Enzyme Inhibitors (ACEI) that includes benazepril, captopril, enalapril, lisinopril, moexipril, perindopril, quinapril, ramipril, and trandoapril. The newer of this class of antihypertensive drugs is the Angiotensin II Receptor Antagonists and includes candesartan, eprosartan, irbesartan, olmesartan, telmisartan, and valsartan.
evening primrose	BARBITURATES	The oil of evening primrose is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the barbiturates, it could potentially decrease the therapeutic effect. This class of anticonvulsant includes mephobarbital, phenobarbital, primidone.
evening primrose	BENZODIAZEPINES	The oil of evening primrose is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the benzodiazepines, it could potentially decrease the therapeutic effect. The one benzodiazepine that is used as an anticonvulsant is clonazepam.
evening primrose	BUPROPION HYDROCHLORIDE	Evening primrose oil is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. There is an additive effect of this action if taken with a medication like bupropion, also known as Wellbutrin@, which can lower the seizure threshold as well. The risk of having a seizure, particularly in someone with a known seizure disorder is increased.
evening primrose	HYDANTOINS	The oil of evening primrose is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the hydantoins, it could potentially decrease the therapeutic effect. This class of anticonvulsant includes ethotoin and phenytoin.
evening primrose	MISCELLANEOUS ANTICONVULSANTS	The oil of evening primrose is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications, it could potentially decrease the therapeutic effect. This class of anticonvulsant includes carbamazepine, felbamate, gabapentin, levetiracetam, magnesium sulfate, oxcarbazepine, tiagabine hydrochloride, toprimate, valproic acid, and zonisamide.
evening primrose	OXAZOLIDINEDIONES	The oil of evening primrose is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the oxazolidinediones, could potentially decrease the therapeutic effect. This class of anticoagulant was once the drugs of choice for absence seizure but is rarely prescribed now.
evening primrose	SUCCINIMIDES	The oil of evening primrose is rich in the omega 6 fatty acid, gamma linoleic acid (GLA), and case reports have described it as lowering the seizure threshold. Taken with anticonvulsant medications such as the succinimides, could potentially decrease the therapeutic effect. This class of anticonvulsant includes ethosuximide and methsuximide.
fennel	HYDROCHLOROTHIAZIDE	Fennel is a photosensitizing herb. It is the furanocoumarins found often in umbelliferae resembling psoralens that cause this effect. Photosensitizing means the skin will be more sensitive to the effects of the sun. This effect is compounded if this herb is taken simultaneously with a photosensitizing drug like hydrochlorothiazide (HCT). Avoid the combined use of these or avoid the sun if taken together.